Sánchez, on the other hand, stood out in a red, sleeveless gown made by John Galliano in 1994 and previously worn by Sophia Loren.
The satin garment had an asymmetrical bodice with a low neckline, form-fitting fabric across the waist, and a skirt that flowed around her ankles.
She completed the look with diamond earrings, a statement necklace, and a crystal-covered clutch designed by Judith Leiber to look like an astronaut.
Salma Hayek Pinault's chunky gold jewelry clashed with her flowing black ensemble.Salma Hayek Pinault attends the 2025 Breakthrough Prize ceremony in Santa Monica.
Emma McIntyre/Getty Images
Yves Saint Laurent designed her layered look. It featured billowing sheer sleeves, a keyhole cutout at the chest, and a tiered skirt with a thick waistband.
Though the black outfit was chic and suited the actor, it was far simpler than her statement gold accessories.
She wore shining platform heels, a chunky necklace with a large floral charm, a matching ring, and numerous bracelets on both wrists.
The bold jewelry might have looked better with a more form-fitting look that highlighted it better.
Lizzo brought the drama in a mermaid-style gown and colorful makeup.Lizzo attends the 2025 Breakthrough Prize ceremony in Santa Monica.
Emma McIntyre/Getty Images
The musician opted for a strapless gown designed to look like it was wrapped around her body. It had ruching across the chest, waist, and hips, a layered skirt with pleats, and a short train.
The dress was glamorous, bold, and one of the best seen on the red carpet.
Equally as stunning were her accessories and makeup. Lizzo wore elbow-length gloves that matched her dress, as well as red blush, red eye shadow, and blotted lipstick.
She also wore her hair in loose, slicked waves to create the illusion that it was wet.
Christina Aguilera's white gown looked more like a princess costume than a designer red-carpet look.Christina Aguilera attends the 2025 Breakthrough Prize ceremony in Santa Monica.
Taylor Hill/Getty Images
Dolce & Gabbana designed the musician's dress, which was sleeveless, floor-length, and wrapped with a visible corset around her waist.
The latter detail — as well as its sheer, cape-like shoulder pieces — distracted from the gown's glamour. She also wore delicate jewelry and her hair in a half-up, half-down style. Both added to the look's overall princess aesthetic.
The outfit would have worked better at a medieval-themed event or as a princess costume.
Sergey Brin chose a sparkling suit for the occasion.Sergey Brin attends the 2025 Breakthrough Prize ceremony in Santa Monica.
Taylor Hill/Getty Images
Brin, the billionaire cofounder of Alphabet, was one of the best-dressed men at the Breakthrough Prize ceremony.
He wore a black suit that mixed traditional menswear styles with modern red-carpet aesthetics. His trousers were solid and straight, while his satin button-down added a fun texture to the top half of his look.
The most interesting part of his look was his suit jacket, which was decorated with pearls, crystals, and beads to create a leaf pattern.
MrBeast played it too safe with his fashion.MrBeast attends the 2025 Breakthrough Prize ceremony in Santa Monica.
Jesse Grant/Getty Images
He sported a traditional tuxedo comprised of pleated dress pants, a suit jacket with satin lapels, a white button-down shirt, and a black bowtie.
Though the social-media star has worn dress clothes for other occasions, MrBeast noted on Instagram that the Breakthrough event marked his first time wearing an actual tuxedo.
Kate Hudson glimmered in gold.Kate Hudson attends the 2025 Breakthrough Prize ceremony in Santa Monica.
Gilbert Flores/Getty Images
The actor sparkled in Elie Saab Couture. Her off-the-shoulder gown was made from tan mesh, embellished with metallic sequins, and shaped in loose puffs.
Between its oversize details and sparkling lines, the dress looked as though it was cascading across Hudson's body.
She wore it with silver rings, gold earrings, and a brushed-back hairstyle.
Katy Perry made a statement in silver, but it wasn't her best look.Katy Perry attends the 2025 Breakthrough Prize ceremony in Santa Monica.
Emma McIntyre/Getty Images
Perry wore Gaurav Gupta for the Breakthrough ceremony. Her asymmetrical dress had a thick neckpiece, deep cutouts across its bodice, a backless top, and a floor-length skirt.
With the dress, the musician proved that silver is absolutely one of her colors. However, its skin-colored mesh was visible beneath its daring chest piece, which distracted from the outfit.
Its swirled design and matching headpiece also didn't appear to fit Perry perfectly.
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