A new model to explore the epidermal renewal

The mechanisms underlying skin renewal are still poorly understood. Interleukin-38 (IL-38), a protein involved in regulating inflammatory responses, could be a game changer. A team has observed it for the first time in the form of condensates in keratinocytes, the cells of the epidermis. The presence of IL-38 in these aggregates is enhanced close to the skin's surface exposed to atmospheric oxygen. This process could be linked to the initiation of programmed keratinocyte death, a natural process in the epidermis. This study could bring new perspectives for the study of human epidermis and the illnesses that affect it.

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Nov 19, 2024 - 03:00
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A new model to explore the epidermal renewal
The mechanisms underlying skin renewal are still poorly understood. Interleukin-38 (IL-38), a protein involved in regulating inflammatory responses, could be a game changer. A team has observed it for the first time in the form of condensates in keratinocytes, the cells of the epidermis. The presence of IL-38 in these aggregates is enhanced close to the skin's surface exposed to atmospheric oxygen. This process could be linked to the initiation of programmed keratinocyte death, a natural process in the epidermis. This study could bring new perspectives for the study of human epidermis and the illnesses that affect it.
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