By exerting 'crowd control' over mouse cells, scientists make progress towards engineering tissues
Genes aren't the sole driver instructing cells to build multicellular structures, tissues, and organs. Biologists have now characterized the influence of another important developmental driver: cell density, or how loosely or tightly cells are packed into a given space. In both computational models and laboratory experiments, the team of scientists used cell density as an effective tool for controlling how mouse cells pattern themselves into complex structures. The research represents progress towards the big picture goal of engineering synthetic tissues. Synthetic tissues could have endless medical applications, ranging from testing potential drugs or therapies to providing grafts or transplants for patients.
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Genes aren't the sole driver instructing cells to build multicellular structures, tissues, and organs. Biologists have now characterized the influence of another important developmental driver: cell density, or how loosely or tightly cells are packed into a given space. In both computational models and laboratory experiments, the team of scientists used cell density as an effective tool for controlling how mouse cells pattern themselves into complex structures. The research represents progress towards the big picture goal of engineering synthetic tissues. Synthetic tissues could have endless medical applications, ranging from testing potential drugs or therapies to providing grafts or transplants for patients.
