Drug reverses groin hernias in male mice without surgery, shows promise in humans
By age 75, a noteworthy 50% of men develop an inguinal (groin) hernia. Although common, the cause of these hernias is unknown, and the only treatment is surgery to repair the weakened area. Even after surgery, these hernias recur in 10 to 15% of men. Using a novel, medication-based approach, a new study successfully reversed existing inguinal hernias in male mice and fully restored their normal anatomy without surgery. Even more promising, the scientists also examined human hernia tissue and found the identical molecular markers as in the mouse model. More than a million inguinal hernia repair surgeries per year are performed under general anesthesia in the U.S.
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By age 75, a noteworthy 50% of men develop an inguinal (groin) hernia. Although common, the cause of these hernias is unknown, and the only treatment is surgery to repair the weakened area. Even after surgery, these hernias recur in 10 to 15% of men. Using a novel, medication-based approach, a new study successfully reversed existing inguinal hernias in male mice and fully restored their normal anatomy without surgery. Even more promising, the scientists also examined human hernia tissue and found the identical molecular markers as in the mouse model. More than a million inguinal hernia repair surgeries per year are performed under general anesthesia in the U.S.
