Spliceosome: How cells avoid errors when manufacturing mRNA
A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a basic requirement for producing proteins that fulfill an organism's vital functions. Researchers have succeeded for the first time in depicting a faultily 'blocked' spliceosome at high resolution and reconstructing how it is recognized and eliminated in the cell.
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A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a basic requirement for producing proteins that fulfill an organism's vital functions. Researchers have succeeded for the first time in depicting a faultily 'blocked' spliceosome at high resolution and reconstructing how it is recognized and eliminated in the cell.
