The 4 best dewormers for dogs in 2025
The best dewormers for dogs prevent and kill tapeworms, hookworms, and more. Our top-rated picks include deworming tablets for puppies and adult dogs.
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Intestinal parasites, often called worms, are microscopic organisms that live inside your dog and silently cause harm. Common intestinal parasites in dogs include roundworms, tapeworms, and hookworms. Some worms, like roundworms and hookworms, can also infect humans. If your dog has worms, it's crucial to get rid of them quickly and safely. However, selecting the right parasite prevention can be difficult. The best dewormers for dogs kill the parasites your pet already has, while intestinal parasite preventives prevent future infections.
With guidance from veterinarians, we chose the best deworming medications based on their safety, efficacy, the number of parasites targeted, and ease of use. Our top pick for a broad-spectrum dewormer is Drontal Plus Taste Tabs. One dose can eliminate four types of intestinal parasites, which is more than any other treatment.
Before you begin treatment, your veterinarian should do a fecal test to determine what type of worms your dog has. Your vet can advise you on what product might be best depending on your dog's temperament, lifestyle, and the most common parasites where you live since some products also kill fleas, ticks, and heartworms. All of the treatments we recommend also require a prescription from your veterinarian.
Read more about how Insider Reviews tests and researches pet products.
Our top picks for the best dewormers for dogs
Best broad-spectrum dewormer for dogs: Drontal Plus Taste Tabs - See at Chewy
Best tapeworm dewormer for dogs: Droncit Tablets - See at Chewy
Best oral parasite preventive for dogs: Trifexis Chewable Tablets - See at Chewy
Best topical parasite preventive for dogs: Advantage Multi for Dogs - See at Chewy
Best broad-spectrum dewormer
Drontal Plus is our top pick for the best dewormers for dogs because it eliminates multiple types of parasites in one dose and within seven days. You can give your dog the flavored chewable tablet alone or with a small amount of food.
The broad-spectrum dewormer contains three powerful active ingredients: pyrantel pamoate, praziquantel, and febantel. These ingredients work together to cover four species of tapeworms, two species of hookworms, two species of roundworms, and whipworms.
You'll need a prescription for Drontal Plus from your veterinarian, and a vet visit is also important because your dog may have other parasites that even a broad-spectrum dewormer can't eliminate. Keep in mind that your dog may require one or more follow-up treatments to make sure all the worms are eliminated. And because dogs commonly become infected with tapeworms by ingesting fleas, you'll also want to control and prevent those with one of the best flea and tick treatments for dogs.
Best for tapeworms
One Droncit tablet works to paralyze and eliminate the four most common species of tapeworms within 24 hours. The active ingredient in Droncit is praziquantel, which is safe and effective for adult dogs and puppies 4 weeks of age and older. You can feed your dog the tablet whole or crumble and mix it with food.
Droncit is conveniently and affordably sold per pill, unlike the other tapeworm medicine we considered, Elanco Tapeworm Dewormer, which contains the same active ingredient praziquantel but is only sold in a five-pack. To prevent future tapeworm infections, be sure to treat any fleas your dog may have and give them a monthly flea prevention medicine.
Best oral parasite preventive
Our pick for best oral parasite preventive is Trifexis, a chewable tablet you give your dog monthly to treat and control hookworms, roundworms, and whipworms. It also kills adult fleas and prevents heartworm. For maximum effectiveness, you should give your dog the beef-flavored chewable tablet with food.
Trifexis uses spinosad and milbemycin oxime to prevent, treat, and control parasites. While it does not kill or treat tapeworms, it kills adult fleas, which are responsible for transmitting the parasite. You'll need a prescription for Trifexis from your veterinarian and a current negative heartworm test. It should be used with caution in dogs with a history of seizures or breeding females. And although it is safe for puppies as young as 8 weeks old and weighing at least 5 pounds, puppies less than 14 weeks of age might experience a higher rate of vomiting than older dogs.
Because Trifexis kills adult fleas, which can transmit tapeworms, it ranked higher than preventives that do not, including Heartgard Plus, Interceptor Plus, Iverhart Max Soft Chews, and Sentinel Spectrum. Simparica Trio treats, controls, and prevents more parasites than any other oral product, including adult fleas, flea larvae, ticks, heartworms, hookworms, roundworms, mange mites, and chewing lice. However, because intestinal parasites are the primary consideration in this guide, Trifexis gets the nod for preventing three intestinal parasites compared to Simparica Trio's two.
Best topical parasite preventive
No single preventive covers every parasite that could harm your dog, but Advantage Multi comes close. Containing the active ingredients imidacloprid and moxidectin, the topical treatment prevents three common intestinal parasites: roundworms, hookworms, and whipworms. It also prevents flea infestations by killing adult fleas before they can lay eggs and prevents heartworm and mange mites.
Choosing between an oral or topical parasite product can be a tough decision. Sometimes, dogs do better with one versus the other. "Some animals can't tolerate or have a food allergy to an oral product, so they must use a topical," says Dr. Melissa Smits, who was a partner at Fort Morgan Veterinary Clinic at the time of our interview. "Or their skin may be sensitive to a topical so an oral is better." If your dog has no tolerance issues, it usually comes down to your preference.
Advantage Multi is easy to use: You apply it every 30 days to the skin at the base of your dog's neck between the shoulder blades. The liquid is absorbed and dries within hours. Unlike with some other topical preventives, you do not need to wear gloves to apply it. If you get the product on your hands, simply wash them with soap and water. For the first 30 minutes after application, keep dogs from licking the application site, either on themselves or other treated dogs in the house. Children should not touch the application site for two hours after application.
As with all medications that prevent heartworm, your dog needs a heartworm test before starting Advantage Multi and annually after that.
What to look for in dewormers for dogs
If you think your dog might have worms, see your veterinarian for an exam and fecal test before buying one of the best dewormers for dogs. A fecal test looks at a sample of your dog's stool under a microscope to identify what type of worms your dog has. Your vet can also assess your dog for other problems caused by a parasite infection.
"I love clients for advocating for their pet and trying, but it's important to bring your dog into the vet because intestinal parasite infections can often go undiagnosed until more severe symptoms appear like weight loss, diarrhea, and vomiting," says Dr. Kelley Lay, a Tennessee-based veterinarian, who has worked in a variety of clinic settings over the last decade, including private practice, as a relief veterinarian, and now in nonprofit work.
Lay says over-the-counter (OTC) dewormers are generally not as effective as prescription medicines, and sometimes, an OTC drug might not treat the correct life stages of the parasite. Additionally, if the type of worm your dog has is misidentified, a product might not help at all. Some "worms" are actually single-celled microscopic parasites (protozoa), though they cause many of the same symptoms as intestinal parasites. Things like coccidia and Giardia need to be treated with entirely different medications.
Depending on the type of worms your dog has, effective deworming might take multiple rounds of medication. Your vet will likely want to perform a follow-up fecal exam to be sure all the worms are gone.
Is the product safe and effective? Before giving any deworming medication to your dog, check to make sure it's approved by the Food and Drug Administration (FDA) or the Environmental Protection Agency (EPA). The FDA's Center for Veterinary Medicine approves and regulates drugs for animals. For oral products, the searchable Animal Drugs @ FDA database will tell you if a medication is approved. Topical flea and tick products for animals are regulated by the EPA. To confirm that a flea and tick product is EPA-registered, search the EPA's Pesticide Product and Label System.
Is the product easy to use? Deworming medications for dogs may be given orally as a pill or flavored chew or topically as a solution applied to the skin. Most dogs will eat a flavored chewable tablet or swallow a pill that has been mixed into their food, but if you have the rare dog that rejects pills, a topical dewormer might be easier. When using a topical medication, read the directions carefully to ensure you apply the product properly and follow all precautions. You might need to keep other pets, children, or pregnant people away from treated dogs for a specified period of time.
Is the product legitimate or counterfeit? Counterfeit medications can be ineffective or even harmful to pets and people. Always purchase pet meds from your veterinarian or a trustworthy pharmacy accredited by the National Association of Boards of Pharmacy (NABP) Verified Websites Program, such as Chewy, Petco, and Petsmart. For advice about choosing a reputable pharmacy for pet medication, check out these tips from the American Veterinary Medical Association (AVMA), the FDA, and the EPA. Some red flags include missing directions, foreign-labeled products, and non-English language directions, and packaging that is not child-resistant.
How we selected the best dewormers for dogs
While researching and writing this guide to the best dewormers for dogs, I drew from my eight years of experience as an assistant in veterinary hospitals and two decades of experience as a writer and editor in the pet and veterinary fields. I conducted research using the Quick Product Reference Guide published by the independent, nonprofit Companion Animal Parasite Council. This helpful reference, which includes all FDA- and EPA-approved parasite control products for small animals, lists each product's active ingredients, how the product is used, and which parasites it controls.
I also consulted with two licensed veterinarians for advice regarding the treatment and prevention of intestinal parasites like tapeworms, roundworms, and hookworms, as well as heartworms and ectoparasites like fleas, ticks, and mites. Although this information guided our product selection, our experts did not specifically endorse or recommend any of the products in this guide.
Here are the main attributes I looked for:
Safety and efficacy: Only FDA-approved products were considered for this guide.
Number of parasites treated: In general, products that covered more parasites received higher ratings. This did not apply to tapeworm dewormers, which are only intended to treat one parasite.
Ease of use: Products received lower ratings if they were more complicated to use than a similar product. For example, lower ratings were given if gloves need to be worn to apply the product or if children and pets need to be kept away from the treated animal for a period of time after application.
Minimum age and weight: When comparing similar products, higher scores went to preventives that can be used in younger animals.
Dog dewormer FAQs
What is the most effective dewormer for dogs?
Although different parasite preventives cover many different parasites, no one product covers every single internal and external parasite that could affect your dog. Talk to your veterinarian to help you decide which product will be best for your dog. "This is the most important part of having a relationship with a veterinarian in your area," Smits says. "We are trained to know what parasite problems we have in our area are, what lifestyle risks are important to consider, and overall, what is best for an individual pet and lifestyle."
Can I deworm my dog myself?
Even though some of the best dewormers for dogs are available without a prescription, do not skip the vet visit since different drugs treat different worms. Your vet will perform a physical exam and a fecal test to determine what type of worms they have. "Not all intestinal parasites are created equal, and there is not a one-size-fits-all when it comes to deworming medications," Lay says. Although a broad-spectrum dewormer kills several different types of worms, certain single-celled microscopic parasites (protozoa), including coccidia and Giardia, are not true worms. They require different prescription medications to treat them. Your dog also might need follow-up deworming and another fecal exam to ensure no parasites remain.
Do natural dewormers work for dogs?
Natural dewormers aren't necessarily a better option, so you should check with your veterinarian before giving one to your dog. "While 'natural' deworming products may have some effect on intestinal parasites, I've consulted with numerous clients over the years who have tried them with repeated failure," Lay says. She adds that conventional, veterinarian-recommended dewormers have gone through stringent drug trials and studies to prove they are effective and safe to use.
What can I give my dog to prevent worms?
Veterinarians recommend keeping dogs on a broad-spectrum parasite preventive all year, not only in the spring and summer months. Different parasites are active during different months, and parasite activity varies. Parasites can also become active earlier than expected, including during the winter. "Many adult dogs may be asymptomatic carriers," Lay says. "Parasites are not always able to be seen in feces and so you may not even know the problem is there. This can lead to infections that linger undetected for a long time."
What are the different types of worms and their signs and symptoms?
Most dogs will contract intestinal parasites at some point in their lives. Some of the most common worms seen in dogs are roundworms, tapeworms, hookworms, and whipworms. In adult dogs, parasite infestations may cause mild to moderate digestive symptoms like vomiting, diarrhea, and gas. However, heavy infestations can lead to severe issues, especially in young puppies.
"They can cause intestinal problems, malnutrition, anemia, growth problems in puppies, and even potential autoimmune issues," Smits says. "Also important is the zoonotic risk, potential spread to human family members."
Roundworms: These parasites are common in dogs, especially puppies, and are 3- to 6-inches long, smooth, and round-bodied. You might not know your dog has roundworms, particularly if they have only a few. In puppies, large numbers of worms may cause a pot-bellied appearance, vomiting, diarrhea, low appetite, dull coat, and restricted growth. You might also see roundworms in your dog's stool or vomit. Roundworms are zoonotic, which means they can be spread to human family members.
Tapeworms: Dogs pick up tapeworms when they ingest an infected adult flea. As the tapeworm grows, segments break off and pass in your dog's stool. If you see something in your dog's feces that resembles grains of white rice or you notice them licking or biting the area under their tail, they could have a tapeworm infestation.
Hookworms: Hookworms are blood-sucking parasites that attach to the wall of the intestines. These tiny worms are nearly invisible without the assistance of a microscope. Signs of hookworm infection in dogs include anemia, weight loss, bloody diarrhea, dull coat, and growth restriction. Hookworms are zoonotic so they can be spread to human family members.
Whipworms: Whipworms are relatively large intestinal parasites (about a ¼-inch long) that reside in the cecum and large intestine, where they wreak serious havoc. Dogs with heavy whipworms are likely to experience concerning symptoms, such as watery, bloody diarrhea, weight loss, and anemia.
Chewy
No other dog dewormer kills as many different types of worms as Drontal Plus.
Pros: Veterinarian recommended, kills four types of worms, safe and reliable, kills all parasites within seven days, low risk for side effects
Cons: Not for puppies younger than 3 weeks old or those weighing less than 2 pounds
Drontal Plus is a safe and effective broad-spectrum dewormer that eliminates multiple types of parasites with one dose. It kills tapeworms, hookworms, roundworms, and whipworms within seven days. Just offer the Drontal Plus Taste Tab flavored chewable tablet to your dog alone or with a small amount of food.
Drontal Plus features three powerful active ingredients: pyrantel pamoate, praziquantel, and febantel, which together cover four species of tapeworms, two species of hookworms, two species of roundworms, and whipworms.
The dewormer has a very low risk for side effects and is safe for puppies as young as 3 weeks old and weighing at least 2 pounds. It requires a prescription from your veterinarian, and a vet visit is also important because your dog may have other parasites that even a broad-spectrum dewormer can't eliminate.
When using a broad-spectrum dewormer like Drontal Plus, your dog may require one or more follow-up treatments to make sure all the worms are eliminated. If your dog has fleas, they should also be treated with a flea control product to prevent future tapeworm infections.
Chewy
A single dose of Droncit safely and quickly kills tapeworms within 24 hours.
Pros: Kills four species of tapeworms, works within 24 hours, easy-to-administer tablet, long-trusted brand, affordably priced per pill
Cons: Some dogs may experience salivation, vomiting, or diarrhea after taking; not for puppies less than 4 weeks old
One Droncit tablet works to paralyze and eliminate the four most common species of tapeworms within 24 hours. Its active ingredient, praziquantel, is effective and safe for adult dogs and puppies 4 weeks of age and older. The tablet can be fed whole or crumbled and mixed with food.
The treatment is conveniently and affordably sold per pill, unlike the other tapeworm dewormer we considered, Bayer Tapeworm Dewormer, which contains the same active ingredient praziquantel but is only sold in a five-pack.
Dogs commonly become infected with tapeworms by ingesting fleas. For this reason, it's important to treat your dog for fleas to prevent future infections.
Chewy
Trifexis treats and controls three common intestinal parasites, kills adult fleas, and prevents heartworm infection with just one monthly chewable pill.
Pros: Protects against three intestinal parasites, heartworms, and adult fleas; once-monthly treatment; safe for dogs and puppies 8 weeks of age and older weighing at least 5 pounds; tablet is easy to administer
Cons: Does not kill or treat tapeworms, not labeled for use in puppies younger than 8 weeks or weighing less than 5 pounds
Our pick for best oral parasite preventive for dogs is Trifexis, a chewable tablet that treats and controls hookworms, roundworms, and whipworms. It also kills adult fleas and prevents heartworm.
Given once every 30 days, Trifexis uses spinosad and milbemycin oxime to prevent, treat, and control parasites. While it does not kill or treat tapeworms, it kills adult fleas, which are responsible for transmitting the parasite. The beef-flavored flavored chewable tablet should be given with food for maximum effectiveness.
Trifexis is safe for puppies as young as 8 weeks old and weighing at least 5 pounds. However, puppies less than 14 weeks of age might experience a higher rate of vomiting than older dogs. This parasite preventive requires a prescription from your veterinarian as well as a current negative heartworm test. It should be used with caution in dogs with a history of seizures or breeding females.
Chewy
With just one simple monthly application, Advantage Multi for Dogs treats, controls, and prevents more parasites than any other topical product.
Pros: Kills and prevents six types of parasites, once-monthly treatment, easy to administer, safe for use in puppies older than 7 weeks and weighing at least 3 pounds
Cons: Does not kill ticks; not labeled for use in puppies younger than 7 weeks or breeding, pregnant, or nursing dogs
No single preventive covers every parasite that could harm your dog, but Advantage Multi comes close. Containing the active ingredients imidacloprid and moxidectin, the topical treatment prevents three common intestinal parasites: roundworms, hookworms, and whipworms. It also prevents flea infestations by killing adult fleas before they can lay eggs and prevents heartworm and mange mites.
Choosing between an oral or topical parasite product can be a tough decision. Sometimes dogs do better with one versus the other. "Some animals can't tolerate or have a food allergy to an oral product so they must use a topical," said veterinarian Melissa Smits, a partner at Fort Morgan Veterinary Clinic in Colorado. "Or their skin may be sensitive to a topical so an oral is better." If there are no tolerance issues, it usually comes down to owner preference.
Advantage Multi is easy to use: Just apply it every 30 days to your dog's skin at the base of the neck between the shoulder blades. The liquid medication is absorbed and dries within hours. Unlike with some of the other topical preventives, you do not need to wear gloves to apply Advantage Multi. If you get the product on your hands, simply wash them with soap and water. For the first 30 minutes after application, keep dogs from licking the application site, either on themselves or other treated dogs in the house. Children should not touch the application site for two hours after application.
You must obtain a prescription from your veterinarian to purchase Advantage Multi. As with all medications that prevent heartworm, your dog needs a heartworm test prior starting Advantage Multi and annually thereafter.
SeventyFour/Getty Images
What is the most effective dewormer for dogs?
Although different parasite preventives cover many different parasites, no one product covers every single internal and external parasite that could affect your dog. Talk to your veterinarian to help you decide which product will be best for your dog. "This is the most important part of having a relationship with a veterinarian in your area," Smits said. "We are trained to know what parasite problems we have in our area are, what lifestyle risks are important to consider, and overall, what is best for an individual pet and lifestyle."
Can I deworm my dog myself?
Even though some dewormers are available without a prescription, do not skip the vet visit since different drugs treat different worms. Your vet will perform a physical exam and a fecal test to determine what type of worms they have. "Not all intestinal parasites are created equal and there is not a one-size-fits-all when it comes to deworming medications," Lay said. Although a broad-spectrum dewormer kills several different types of worms, certain single-celled microscopic parasites (protozoa), including coccidia and Giardia, are not true worms. They require different prescription medications to treat them. Your dog also might need follow-up deworming and another fecal exam to ensure no parasites remain.
Do natural dewormers work for dogs?
Natural dewormers aren't necessarily a better option, so you should check with your veterinarian before giving one to your dog. "While 'natural' deworming products may have some effect on intestinal parasites, I've consulted with numerous clients over the years who have tried them with repeated failure," Lay said. She added that conventional, veterinarian-recommended dewormers have gone through stringent drug trials and studies to prove they are effective and safe to use.
What can I give my dog to prevent worms?
Veterinarians recommend keeping dogs on a broad-spectrum parasite preventive all year, not only in the spring and summer months. Different parasites are active during different months, and parasite activity varies. Parasites can also become active earlier than expected, including during the winter. "Many adult dogs may be asymptomatic carriers," according to Kelley Lay, a relief veterinarian who practices in Nashville, Tennessee. "Parasites are not always able to be seen in feces and so you may not even know the problem is there. This can lead to infections that linger undetected for a long time."
Christiane Bongertz/EyeEm/Getty Images
Most dogs will contract intestinal parasites at some point in their lives. Some of the most common worms seen in dogs are roundworms, tapeworms, hookworms, and whipworms. In adult dogs, parasite infestations may cause mild to moderate digestive symptoms like vomiting, diarrhea, and gas. However, heavy infestations, especially in young puppies, can lead to severe issues.
"They can cause intestinal problems, malnutrition, anemia, growth problems in puppies, and even potential autoimmune issues," Smits said. "Also important is the zoonotic risk — potential spread to human family members."
- Roundworms: These parasites are common in dogs, especially puppies, and are 3- to 6-inches long, smooth, and round-bodied. You might not know your dog has roundworms, particularly if they have only a few. In puppies, large numbers of worms may cause a pot-bellied appearance, vomiting, diarrhea, low appetite, dull coat, and restricted growth. You might also see roundworms in your dog's stool or vomit. Roundworms are zoonotic, which means they can be spread to human family members.
- Tapeworms: Dogs pick up tapeworms when they ingest an infected adult flea. As the tapeworm grows, segments break off and pass in your dog's stool. If you see something in your dog's feces that resembles grains of white rice, or you notice them licking or biting the area under their tail, they could have a tapeworm infestation.
- Hookworms: Hookworms are blood-sucking parasites that attach to the wall of the intestines. These tiny worms are nearly invisible without the assistance of a microscope. Signs of hookworm infection in dogs include anemia, weight loss, bloody diarrhea, dull coat, and growth restriction. Hookworms are zoonotic so they can be spread to human family members.
- Whipworms: Whipworms are relatively large intestinal parasites (about a ¼-inch long) that reside in the cecum and large intestine, where they wreak serious havoc. Dogs with heavy whipworms are likely to experience concerning symptoms, such as watery, bloody diarrhea, weight loss, and anemia.
